Research highlights

New breakthrough in measuring information flow

We are proud to share that AMOLF researchers have published a new paper in Physical Review Letters, entitled “Exact Computation of Transfer Entropy with Path Weight Sampling.” The study presents TE-PWS, a computational technique that – for the first time – enables the exact computation of transfer entropy, a central measure in information theory. Transfer entropy is used to quantify how information flows from one part of a system to another, and to detect causal relationships between variables.

Why transfer entropy matters

Group leader Pieter Rein ten Wolde: “This is a breakthrough, because the transfer entropy is the canonical measure for quantifying information transmission and for detecting causal relationships between variables: do the storks deliver babies, or do the storks come in the spring and are babies more often born in the spring?”

Avishek Das and Pieter Rein ten Wolde at AMOLF

From approximation to exact results

Until now, transfer entropy could only be approximated in complex networks, leading to unreliable results. TE-PWS overcomes this by borrowing a concept from statistical physics known as importance sampling, which allows extremely rare fluctuations to be captured efficiently in simulations.

Postdoctoral researcher Avishek Das explains: “Our daily lives rely on complex networks, from the internet and financial markets to ecosystems and the human brain. To understand and control how these networks process information, we need reliable ways to measure information flow. TE-PWS finally makes that possible in any general model.”

The team showed that TE-PWS not only provides exact results but is also as fast – or even faster – than existing approximate methods. This makes it the only reliable and efficient tool available for measuring transfer entropy across a wide range of systems, from cellular reaction networks to stock markets.

TE-PWS takes in a dynamical model and outputs an exact estimate of information transfer (AMOLF)
TE-PWS takes in a dynamical model and outputs an exact estimate of information transfer

Borrowing tools from statistical physics

Beyond its immediate impact in physics and biology, the method could also inspire practical applications. Avishek highlights: “What excites me most is the interdisciplinary nature of this work. We borrowed an idea from physical chemistry to solve an open problem in information theory, and in turn, this solution will help us understand both engineered and biological systems better.”

Potential applications across science and technology

With TE-PWS, scientists and engineers now have a ground-truth method to test their theories, compare approximations, and even design smarter artificial networks. The team envisions applications ranging from understanding brain function to creating bio-inspired materials and autonomous robots.

The code for TE-PWS is openly available through the publication.

Learn more

Share article
What's happening

Most recent news items

All news items
Collaboration

Successful outcomes of international EBEAM program led by AMOLF

The EU Pathfinder project Electron Beams Enhancing Analytical Microscopy (EBEAM) that was recently completed has received a highly positive review of the European Innovation Council (EIC). EBEAM brought together eight European research institutions and companies, including AMOLF, that develop new concepts and instruments combining spectroscopic analysis with electron microscopy.

Read news item
Research highlights

Everything you need to know about organoids

Organoids are instrumental in improving our understanding of processes that are otherwise hidden inside the body. For instance, these small 3D organs can be used to test medicines on tissue grown from a patient’s own cells. AMOLF researchers carry out unique and complex experiments to follow organoids in time. In order to enable other researchers to benefit from their experiences, they now publish their methods in the prestigious journal Nature Protocols.

Read news item
Events and outreach

Minister Rianne Letschert wears hat and shoulder ornament inspired by Wim Noorduin’s research

This year at the opening of the parliamentary year (Prinsjesdag) Minister of Education, Culture and Science Rianne Letschert wears a spectacular hat and shoulder ornament. Both of them are inspired by the microscopic structures studied by group leader Wim Noorduin (AMOLF/UvA), which look remarkably like tiny flowers under a microscope. Artist and designer Malou Beemer translated these shapes, normally invisible to the naked eye, into wearable art.

Read news item
Nachi Stern, Group Leader Learning Machines at AMOLF
People and recognition

Nachi Stern awarded ERC Starting Grant to explore how matter learns

Why do brains learn, but rocks do not? Could a material one day adapt to its environment the way a living organism does? AMOLF group leader Dr. Nachi Stern has been awarded an ERC Starting Grant to investigate the physical laws of learning, in a project called, “Physical Learning in Dynamical Systems.”

Read news item
Stay informed

Get the latest research highlights, events, and news from our institute delivered to your inbox