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Latest developments from our institute

Stay informed about new research results, awards, events, and collaborations across our scientific community.

Research highlights

How do stem cells choose their identity?

AMOLF researchers discovered that stem cells first specialize into a functional cell and then move to the proper location – rather than the other way around.

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Events and outreach

OrganoidNL 2023: A successful showcase of organoid research in the Netherlands

On March 31st, 2023, the first OrganoidNL Symposium was organized at the AMOLF institute in Amsterdam. This one-day event brought together researchers from across the Netherlands with an interest in embryo-like structures and organoid technology and biology. With this symposium, the organizers aimed to further galvanize the already strong organoid research in the Netherlands by providing a platform for knowledge exchange and collaboration.

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Research highlights

Daughter cells in the intestine do what their mother tells them

AMOLF researchers have discovered what prevents cells in the intestine from dividing rampantly. One hypothesis was that this happens because, on average, for each cell that divides, another cell stops dividing. However, this model failed to provide a good answer to the question as to why cell growth fluctuates so little. Jeroen van Zon and his colleagues have now discovered how that mechanism works by making time-lapse videos of the cells. They noted that two daughter cells from the mother cell always do the same. Either they both divide, or neither divides. As a result of this, cell growth is constant with less chance of cancer and other diseases.

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Research highlights

Optimization of human small intestinal organoids

Collaborating scientists have improved human small intestinal organoids – miniature versions of the small intestine. This will help them to better study the functioning of the small intestine. The scientists from the Hubrecht and AMOLF institutes, and various other collaborators developed organoids that contain mature Paneth cells, which were not present in the earlier human small intestinal organoids. The results of the study were published on 23 August in Cell Stem Cell.

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