Our lab employs simple experimental model systems to study fundamental evolutionary processes, using concepts from biology, engineering, and physics

The aim of this project is to understand the molecular mechanisms that underlie transcription noise, and to unravel its impact on the efficiency of organism growth.

We have several interesting Masters projects on these topics with experimental or theoretical character, or both.

You will employ PCR, grow the bacteria in various media, and analyze the evolutionary progress in the context of a fitness landscape.

Large families of transcription factors, which regulate gene expression by binding to DNA, have been formed by gene duplications and mutational divergence. You will measure this cross-repression within the lac repressor family,...

Recently it has become possible to follow the folding of a single protein using single-molecule techniques. However, folding pathways are generally studied for isolated proteins, even though interactions with chaperones are known...