Internship Cell-matrix interactions on micropatterned substrates
Cells are known to be sensitive to the architecture and elastic behavior of this scaffold. But how do cells “feel†collagen fibers?
Research / Job description
Tissues such as skin or bone largely consist of a polymer network formed by stiff collagen fibers, which provide both biochemical and physical support to living cells. Cells are known to be sensitive to the architecture and elastic behavior of this scaffold. But how do cells “feel†collagen fibers? To answer this question, we will attach cells on micro-patterned surfaces made by photolithography and microcontact printing in the cleanroom. We can thus control the cell shape and cell-cell interactions. Reconstituted collagen fibers will be deposited on top of the cells and microscopy will be used to see how cells exert contractile forces on individual collagen fibers. In addition, optical tweezers will be employed to determine the mechanical properties of individual collagen fibers and the cells.
About the group Biological Soft Matter
Required qualifications
You have a Bachelors-degree in physics, chemistry or biology and participate in a Master in one of these areas. You have a nationality of an EU-member state or if not, you are a student at a Netherlands University. You must be available for at least 6 months.
Terms of employment
In the beginning of your placement, along with your supervisor at AMOLF, you will make a step-by-step plan in which working conditions and supervision will be agreed on. If the training period is to last longer than two months, an agreement will also be established in which things like compensation will be fixed.
For further information please contact:
Dr. Gijsje Koenderink
Phone: +31 (0)20 754 7100
Applications can be sent to:
FOM Institute AMOLF
Personnel department
Postbus 41883
1009 DB Amsterdam
The Netherlands
trainee.applicantATamolf.nl
Please quote vacancy #0705.3700/1
Please send your:
- Résumé;
- List of courses followed so far, and grades obtained.