Publications Biomolecular Imaging Mass Spectrometry (BIMS)

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Article(s) published in 2011

D.F. Smith, E.W. Robinson, A.V. Tolmachev, R.M.A. Heeren and L. Pasa-Tolic, C60 Secondary Ion Fourier Transform Ion Cyclotron Resonance Mass Spectrometry, Anal. Chem. 83, 9552–9556 (2011).
J. Cox, R.M.A. Heeren, P. James, J.V. Jorrin-Novo, E. Kolker, F. Levander, N. Morrice, P. Picotti, P.G. Righetti, J.- C. Sánchez, C.W. Turck, R. Zubarev, B.M. Alexandre, F.J. Corrales, G. Marko-Varga, S. O'Donovan, S. O'Neil, J. Prechl, T. Simões, W. Weckwerth and D. Penque, Facing challenges in Proteomics today and in the coming decade: Report of Roundtable Discussions at the 4th EuPA Scientific Meeting, Portugal, Estoril 2010, J. Proteomics 75, 4-17 (2011).
F.N. Svara, A. Kiss, T. Jaskolla, M. Karas and R.M.A. Heeren, High-reactivity matrices increase the sensitivity of matrix enhanced secondary Ion Mass Spectrometry, Anal. Chem. 83, 8308-8313 (2011).
G.N. Vladimirov, C.L. Hendrickson, G.T. Blakney, A.G. Marshall, R.M.A. Heeren and E.N. Nikolaev, Fourier transform ion cyclotron resonance mass resolution and dynamic range limits calculated by computer modeling of ion cloud motion, J. Am. Soc. Mass Spectrom. Online first, 10.1007/s13361-011-0268-8 (2011).
W. Bult, H. de Leeuw, O.M. Steinebach, H.T. Wolterbeek, R.M.A. Heeren, A.D. van het Schip, W.E. Hennink and J.F.W. Nijsen, Radioactive holmium acetylacetonate microspheres for interstitial microbrachytherapy : an in vitro and in vivo stability study, Pharm. Res. published online, DOI: 10.1007/s11095-011-0610-7 (2011).
J.H. Jungmann, L. MacAleese, J. Visser, M.J.J. Vrakking and R.M.A. Heeren, High dynamic range bio-molecular ion microscopy with the Timepix Detector, Anal. Chem. 83, 7888-7894 (2011).
A. Nasioudis, J.W. van Velde, R.M.A. Heeren and O.F. van den Brink, Detailed molecular characterization of castor oil ethoxylates by liquid chromatography multistage mass spectrometry, J. Chrom. A 1218, 7166-7172 (2011).
G.N. Vladimirov, A.V. Kharchenko, R.M.A. Heeren and E.N. Nikolaev, Simulation of ion dynamics in the orbital ion trap with regard to the space-charge and trapping electric field inharmonicity, Trans. MIPT 3, 157-162 in Russian (2011).
E.R. Amstalden van Hove, D.F. Smith, L. Fornai, K. Glunde and R.M.A. Heeren, An alternative paper based tissue washing method for Mass Spectrometry Imaging: Localized washing and fragile tissue analysis, J. Am. Soc. Mass Spectrom. 22, 1885-1890 (2011).
L.L.A. Spijkers, R.F.P. van den Akker, B.J.A. Janssen, J.J. Debets, J.G.R. de Mey, E.S.G. Stroes, B.-J.H. van den Born, D.S. Wijesinghe, C.E. Chalfant, L. MacAleese, G.B. Eijkel, R.M.A. Heeren, A.E. Alewijnse and S.L.M. Peters, Hypertension is associated with marked alterations in sphingolipid biology: a potential role for ceramide, PLoS One 6, e21817 1-9 (2011).
L. MacAleese, M.C. Duursma, L.A. Klerk, G. Fisher and R.M.A. Heeren, Protein identification with Liquid Chromatography and Matrix Enhanced Secondaty Ion Mass Spectrometry (LC-ME-SIMS), J. Proteomics 74, 993-1001 (2011).
K. Aizikov, D.F. Smith, D.A. Chargin, S. Ivanov, T-Y. Lin, R.M.A. Heeren and P.B. O'Connor, Vacuum compatible sample positioning device for matrix assisted laser desorption/ionization Fourier transform ion cyclotron resonance mass spectrometry imaging, Rev. Sci. Instr. 82, 054102 1-8 (2011).
A. Nasioudis, J.W. van Velde, R.M.A. Heeren and O.F. van den Brink, Electrospray ionization mass spectrometry of the non-covalent complexes of ammonium ions with high molar mass polyethers, Int. J. Mass Spect. 303, 63-68 (2011).
A. Nasioudis, R.M.A. Heeren, I. van Doormalen, N. de Wijs-Rot and O.F. van den Brink, Electrospray ionization tandem mass spectrometry of ammonium cationized polyethers, J. Am. Soc. Mass Spectrom. 22, 837-844 (2011).
J. Song, J.W. van Velde, L.L.T. Vertommen, D.F. Smith, R.M.A. Heeren and O.F. van den Brink, End-group analysis of methacrylic (co)polymers by LC-ESI-MS2, Macromolecules 44, 1319-1326 (2011).
A. Kiss and R.M.A. Heeren, Size, weight and position: ion mobility spectrometry and imaging MS combined, Anal. Bioanal. Chem. 399, 2623-2634 (2011).
D.F. Smith, K. Aizikov, M.C. Duursma, F.G. Giskes, D.-J. Spaanderman, L.A. McDonnell, P.B. O'Connor and R.M.A. Heeren, An external matrix-assisted laser desorption ionization source for flexible FT-ICR mass spectrometry imaging with internal calibration on adjacent samples, J. Am. Soc. Mass Spectrom. 22, 130-137 (2011).

Article(s) published in 2010

J.H. Jungmann, L. MacAleese, R. Buijs, F.G. Giskes, A. de Snaijer, J. Visser, J. Visschers, M.J.J. Vrakking and R.M.A. Heeren, Fast, high resolution mass spectrometry imaging using a medipix pixelated detector, J. Am. Soc. Mass Spectrom. 21, 2023-2030 (2010).
J. Song, C.H. Grün, R.M.A. Heeren, H.-G. Janssen and O.F. van den Brink, High-resolution ion mobility spectrometry–mass spectrometry on Poly(methyl methacrylate), Angew. Chem., Int. Ed. 49, 10168–10171 (2010).
A. Nasioudis, A. Memboeuf, R.M.A. Heeren, D.F. Smith, K. Vékey, L. Drahos and O.F. van den Brink, Discrimination of polymers by using their characteristic collision energy in tandem mass spectrometry, Anal. Chem. 82, 9350-9356 (2010).
E.R. Amstalden van Hove, T.R. Blackwell, I. Klinkert, G.B. Eijkel, R.M.A. Heeren and K. Glunde, Multimodal mass spectrometric imaging of small molecules reveals distinct spatio-molecular signatures in differentially metastatic breast tumor models, Cancer Res. 70, 9012–9021 (2010).
J. Song, A. Memboeuf, R.M.A. Heeren, K. Vékey and O.F. van den Brink, Discrimination between charge-catalyzed and charge-independent fragmentation processes of cationized poly(n-Butyl acrylate), Rapid Commun. Mass Spectrom. 24, 3214-3216 (2010).
J.H. Jungmann, A. Gijsbertsen, J. Visser, J. Visschers, R.M.A. Heeren and M.J.J. Vrakking, A new imaging method for understanding chemical dynamics : efficient slice imaging using an in-vacuum detector, Rev. Sci. Instrum. 81, 103112 1-7 (2010).
J. Song, J.W. van Velde, L.L.T. Vertommen, L.G.J. van der Ven, R.M.A. Heeren and O.F. van den Brink, Investigation of polymerization mechanisms of poly(n-Buyl Acrylate)s generated in different solvents by LC-ESI-MS2, Macromolecules 43, 7082–7089 (2010).
A. Nasioudis, W.F. Joyce, J.W. van Velde, R.M.A. Heeren and O.F. van den Brink, Formation of low charge state ions of synthetic polymers using quaternary ammonium compounds, Anal. Chem. 82, 5735-5742 (2010).
L.A. Klerk, Patricia Y.W. Dankers, E.R. Popa, A.W. Bosman, M.E. Sanders, K.A. Reedquist and R.M.A. Heeren, TOF-Secondary Ion Mass Spectrometry imaging of polymeric scaffolds with surrounding tissue after in vivo implantation, Anal. Chem. 82, 4337–4343 (2010).
E.R. Amstalden van Hove, D.F. Smith and R.M.A. Heeren, A concise review of mass spectrometry imaging, J. Chromatogr., A 1217, 3946-3954 (2010).
K. Chughtai and R.M.A. Heeren, Mass spectrometric imaging for biomedical tissue analysis, Chem. Rev. 110, 3237–3277 (2010).
J. Stauber, L. MacAleese, J. Franck, E. Claude, M. Snel, B. Kükrer-Kaletas, I.M. van der Wiel, M. Wisztorski, I. Fournier and R.M.A. Heeren, On-tissue protein identification and imaging by MALDI-ion mobility mass spectrometry, J. Am. Soc. Mass Spectrom. 21, 338-347 (2010).
L.A. Klerk, N. P. Lockyer, A.V. Kharchenko, L. MacAleese, Patricia Y.W. Dankers, J.C. Vickerman and R.M.A. Heeren, C60+ secondary ion microscopy using a delay line detector, Anal. Chem. 82, 801-807 (2010).
I.M. Taban Barbu, D.F. Smith, B. van Breukelen, Y.E.M. van der Burgt, M.C. Duursma, A.J.R. Heck, R.M.A. Heeren and J. Krijgsveld, On-the-fly targeted selection of labeled peptides in liquid chromatography/mass spectrometry based quantitative proteomics, Rapid Commun. Mass Spectrom. 24, 239-241 (2010).
M. Froesch, S.L. Luxembourg, D. Verheijde and R.M.A. Heeren, Imaging mass spectrometry using a delay-line detector, Eur. J. Mass Spectrom. 16, 35-45 (2010).

Article(s) published in 2009

R. van Gastel, S.J. van der Molen, I. Sikharulidze, G. Gademann, J.H. Jungmann, R.M.A. Heeren and M.J.J. Vrakking, Ruisloos deeltjes detecteren, NTvN 75, 402-405 (2009).
L.A. Klerk, A.F.M. Altelaar, M. Froesch, L.A. McDonnell and R.M.A. Heeren, Fast and automated large-area imaging MALDI mass spectrometry in microprobe and microscope mode, Int. J. Mass Spectrom. 285, 19-25 (2009).
G.B. Eijkel, B. Kükrer-Kaletas, I.M. van der Wiel, J.M. Kros, T.M. Luider and R.M.A. Heeren, Correlating MALDI and SIMS imaging mass spectrometric datasets of biological tissue surfaces, Surface and Interface Analysis 41, 675-685 (2009).
E.S.B. Ferreira, R.M.A. Heeren, K.-J. van den Berg, C. Maines, K. Sutherland and C. Higgitt, Mass spectrometry of art and cultural heritage, Int. J. Mass Spectrom. 284, 1 (2009).
R.M.A. Heeren, D.F. Smith, J. Stauber, B. Kükrer-Kaletas and L. MacAleese, Imaging mass spectrometry : hype or hope?, Journal of the American Society for Mass Spectrometry 20, 1006-1014 (2009).
M. Hanselmann, U. Köthe, M. Kirchner, B.Y. Renard, E.R. Amstalden van Hove, K. Glunde, R.M.A. Heeren and F.A. Hamprecht, Toward digital staining using imaging mass spectrometry and random forests, Journal of Proteome Research 8, 3558–3567 (2009).
J.F. Graveland-Bikker, R.I. Koning, H.K. Koerten, R.B.J. Geels, R.M.A. Heeren and C.G. de Kruif, Structural characterization of alpha-lactalbumin nanotubes, Soft Matter 5, 2020-2026 (2009).
B. Kükrer-Kaletas, I.M. van der Wiel, J. Stauber, L. Dekker, C. Güzel, T.M. Luider and R.M.A. Heeren, Sample preparation issues for tissue imaging by imaging MS, Proteomics 9, 2622–2633 (2009).
P. Kouvonen, L.A. McDonnell, R.M.A. Heeren and G.L. Corthals, Nitromatrix provides improved LC-MALDI signals and more protein identifications, Proteomics 9, 1662–1671 (2009).
Y.E.M. van der Burgt, M. Palmblad, H.C. Dalebout, R.M.A. Heeren and A.M. Deelder, Electron capture dissociation of peptide hormone changes upon opening of the tocin ring and complexation with transition metal cations, Rapid Communications in Mass Spectrometry 23, 31--38 (2009).
L. MacAleese, J. Stauber and R.M.A. Heeren, Perspectives for imaging mass spectrometry in the proteomics landscape, Proteomics 9, 819--834 (2009).

Article(s) published in 2008

M. Hanselmann, M. Kirchner, B.Y. Renard, E.R. Amstalden van Hove, K. Glunde, R.M.A. Heeren and F.A. Hamprecht, Concise representation of mass spectrometry images by probabilistic latent semantic analysis, Anal. Chem. 80, 9649–9658 (2008).
I.M. Taban Barbu, Y.E.M. van der Burgt, M.C. Duursma, Z. Takáts, M. Seynen, M. Konijnenburg, A.J.M. Vijftigschild, I. Attema and R.M.A. Heeren, A novel workflow control system for Fourier transform ion cyclotron resonance mass spectrometry allows for unique on-the-fly data-dependent decisions, Rapid Commun. Mass Spectrom 22, 1245--1256 (2008).
R.M.A. Heeren, B. Kükrer-Kaletas, I.M. Taban Barbu, L. MacAleese and L.A. McDonnell, Quality of surface : the influence of sample preparation on MS based biomolecular tissue imaging with MALDI-MS and (ME-)SIMS, Appl. Phys. Lett. 255, 1289--1297 (2008).
A. Broersen, R. van Liere, A.F.M. Altelaar, R.M.A. Heeren and L.A. McDonnell, Automated, feature-based image alignment for high-resolution imaging mass spectrometry of large biological samples, Journal of the American Society for Mass Spectrometry 19, 823--832 (2008).
R.B.J. Geels, S. Calmat, A.J.R. Heck, S.M. van der Vies and R.M.A. Heeren, Thermal activation of the co-chaperonins GroES and gp31 probed by mass spectrometry, Rapid Communications in Mass Spectrometry 22, 3633--3641 (2008).

Article(s) published in 2007

A. Römpp, L. Dekker, I.M. Taban Barbu, G. Jenster, W. Boogerd, H. Bonfrer, B. Spengler, R.M.A. Heeren, P.S. Smitt and T.M. Luider, Identification of leptomeningeal metastasis-related proteins in cerebrospinal fluid of patients with breast cancer by a combination of MALDI-TOF, MALDI-FTICR and nanoLC-FTICR MS, Proteomics 7, 474 - 481 (2007).
R.M.A. Heeren and J.V. Sweedler, Imaging mass spectrometry imaging, Int. J. Mass Spectrom. 260, 89 (2007).
L.A. Klerk, A. Broersen, I.W. Fletcher, R. van Liere and R.M.A. Heeren, Extended data analysis strategies for high resolution imaging MS: New methods to deal with extremely large image hyperspectral datasets, Int. J. Mass Spectrom. 260, 222--236 (2007).
A.F.M. Altelaar, I.M. Taban Barbu, L.A. McDonnell, P.D.E.M. Verhaert, R.P.J. de Lange, R.A.H. Adan, W.J. Mooi, R.M.A. Heeren and S.R. Piersma, High-resolution MALDI imaging mass spectrometry allows localization of peptide distributions at cellular length scales in pituitary tissue sections, Int. J. Mass Spectrom. 260, 203--211 (2007).
I. Klinkert, L.A. McDonnell, S.L. Luxembourg, A.F.M. Altelaar, E.R. Amstalden van Hove, S.R. Piersma and R.M.A. Heeren, Tools and strategies for visualization of large image data sets in high-resolution imaging mass spectrometry, Review of Scientific Instruments 78, 0053716 1--10 (2007).
L.A. McDonnell and R.M.A. Heeren, Imaging mass spectrometry, Mass Spectrometry Reviews 26, 606--643 (2007).
R.B.J. Geels, S.M. van der Vies, A.J.R. Heck and R.M.A. Heeren, Comparative gas-phase activation of two similar non-covalent heptameric protein complexes: gp31 and GroES, Int. J. Mass Spectrom. 265, 159--168 (2007).
I.M. Taban Barbu, A.F.M. Altelaar, Y.E.M. van der Burgt, L.A. McDonnell, R.M.A. Heeren, J. Fuchser and G. Baykut, Imaging of peptides in the rat brain using MALDI-FTICR mass spectrometry, Journal of the American Society for Mass Spectrometry 18, 145--151 (2007).
Y.E.M. van der Burgt, I.M. Taban Barbu, M. Konijnenburg, M. Biskup, M.C. Duursma, R.M.A. Heeren, A. Römpp, R.V. van Nieuwpoort and H.E. Bal, Parallel processing of large datasets from nanoLC-FTICR-MS measurements, Journal of the American Society for Mass Spectrometry 18, 152--161 (2007).
C.J.M. de Groot, C. Güzel, R.P.M. Steegers-Theunissen, M. de Maat, P. Derkx, E.-M. Roes, R.M.A. Heeren, T.M. Luider and Eric A.P. Steegers, Specific peptides identified by mass spectrometry in placental tissue from pregnancies complicated by early onset preeclampsia attained by laser capture dissection, Proteomics - Clinical Applications 1, 325--335 (2007).
R. Mihalca, Y.E.M. van der Burgt, A.J.R. Heck and R.M.A. Heeren, Disulfide bond cleavages observed in SORI-CID of three nonapeptides complexed with divalent transition-metal cations, Journal of Mass Spectrometry 42, 450--458 (2007).
A.F.M. Altelaar, S.L. Luxembourg, L.A. McDonnell, S.R. Piersma and R.M.A. Heeren, Imaging mass spectrometry at cellular length scales, Nature Protocols 2, 1185--1196 (2007).
M. Setou, R.M.A. Heeren, M. Stoeckli, S. Simma and M. Matsumoto, Mass microscopy, Seikagaku 79, 874--879 (2007).
M.C. Duursma, B. Kükrer-Kaletas, E.R. Amstalden van Hove, L. MacAleese and R.M.A. Heeren, On the fringe of regular proteomics and cell microscopy, NPC Highlights 6, 20--23 (2007).
E.N. Nikolaev, R.M.A. Heeren, A.M. Popov, A.V. Pozdneev and K.S. Chingin, Realistic modeling of ion cloud motion in a Fourier transform ion cyclotron resonance cell by use of a particle-in-cell approach, Rapid Communications in Mass Spectrometry 21, 3527--3546 (2007).

Article(s) published in 2006

A. Roempp, L. Dekker, I.M. Taban Barbu, G. Jenster, W. Boogerd, H. Bonfrer, B. Spengler, R.M.A. Heeren, P.S. Smitt and T.M. Luider, Identification of leptomeningeal metastasis-related proteins in cerebrospinal fluid by a combination of MALDI-TOF, MALDI-FTICR and NanoLC-FTICR mass spectrometry, Molecular & Cellular Proteomics 5, S56: 254 (2006).
A.F.M. Altelaar, I. Klinkert, K. Jalink, R.P.J. de Lange, R.A.H. Adan, R.M.A. Heeren and S.R. Piersma, Gold-enhanced biomolecular surface imaging of cells and tissue by SIMS and MALDI mass spectrometry, Anal. Chem. 78, 734--742 (2006).
S.L. Luxembourg and R.M.A. Heeren, Fragmentation at and above surfaces in SIMS : effects of biomolecular yield enhancing surface modifications, Int. J. Mass Spectrom. 253, 181--192 (2006).
A.J. Kleinnijenhuis, R. Mihalca, R.M.A. Heeren and A.J.R. Heck, Atypical behavior in the electron capture induced dissociation of biologically relevant transition metal ion complexes of the peptide hormone oxytocin, Int. J. Mass Spectrom. 253, 217--224 (2006).
R.M.A. Heeren, L.A. McDonnell, E.R. Amstalden van Hove, S.L. Luxembourg, A.F.M. Altelaar and S.R. Piersma, Why don't biologists use SIMS? : A critical evaluation of imaging MS, Appl Surf. Sci. 252, 6827--6835 (2006).
A.F.M. Altelaar, J. van Minnen, R.M.A. Heeren and S.R. Piersma, The influence of the cholesterol microenvironment in tissue sections on molecular ionization efficiencies and distributions in ToF-SIMS, Appl Surf. Sci. 252, 6702--6705 (2006).
M.K. Titulaer, I. Siccama, L. Dekker, Angelique L.C.T. van Rijswijk, R.M.A. Heeren, P.S. Smitt and T.M. Luider, A database application for pre-processing, storage and comparison of mass spectra derived from patients and controls, Bioinformatics 7, 403 1--16 (2006).
R.B.J. Geels, S.M. van der Vies, A.J.R. Heck and R.M.A. Heeren, Electron capture dissociation as structural probe for noncovalent gas-phase protein assemblies, Anal. Chem. 78, 7191--7196 (2006).
E. van Duijn, D.A. Simmons, R.H.H. van den Heuvel, P.J. Bakkes, H. van Heerikhuizen, R.M.A. Heeren, C.V. Robinson, S.M. van der Vies and A.J.R. Heck, Tandem mass spectrometry of intact GroEL-substrate complexes reveals substrate-specific conformational changes in the trans ring, Journal of the American Chemical Society 128, 4694--4702 (2006).
R. Mihalca, Y.E.M. van der Burgt, L.A. McDonnell, M.C. Duursma, I. Cerjak, A.J.R. Heck and R.M.A. Heeren, Combined infrared multiphoton dissociation and electron capture dissociation using co-linear and overlapping beams in Fourier transform ion cyclotron resonance mass spectrometry, Rapid Communications in Mass Spectrometry 20, 1838--1844 (2006).
S.L. Luxembourg, A.F.M. Altelaar, L.A. McDonnell and R.M.A. Heeren, Massamicroscopie: moleculaire flitsfoto's van eiwitverdelingen, Nederlands Tijdschrift voor Natuurkunde 72, 188--192 (2006).
L.A. McDonnell, R.M.A. Heeren, R.P.J. de Lange and I.W. Fletcher, Higher sensitivity secondary ion mass spectrometry of biological molecules for high resolution, chemically specific imaging, Journal of the American Society for Mass Spectrometry 17, 1195--1202 (2006).
S.L. Luxembourg, A.R. Vaezaddeh, E.R. Amstalden van Hove, C.G. Zimmermann-Ivol, D.F. Hochstrasser and R.M.A. Heeren, The molecular scanner in microscope mode, Rapid Communications in Mass Spectrometry 20, 3435--3442 (2006).

Article(s) published in 2005

A.F.M. Altelaar, J. van Minnen, C.R. Jiménez, R.M.A. Heeren and S.R. Piersma, Direct molecular imaging of Lymnaea stagnalis nervous tissue at subcellular spatial resolution by mass spectrometry, Anal. Chem. 77, 735--741 (2005).
I.M. Taban Barbu, L.A. McDonnell, A. Römpp, I. Cerjak and R.M.A. Heeren, SIMION analysis of a high performance linear accumulation octopole with enhanced ejection capabilities, Int. J. Mass Spectrom. 244, 135--143 (2005).
A. Römpp, I.M. Taban Barbu, R. Mihalca, M.C. Duursma, T.H. Mize, L.A. McDonnell and R.M.A. Heeren, Examples of Fourier transform ion cyclotron resonance mass spectrometry developments: from ion physics to remote access biochemical mass spectrometry, Eur. J. Mass Spectrom. 11, 443--456 (2005).
L.A. McDonnell, S.R. Piersma, A.F.M. Altelaar, T.H. Mize, S.L. Luxembourg, P.D.E.M. Verhaert, J. van Minnen and R.M.A. Heeren, Subcellular imaging mass sectrometry of brain tissue, Journal of Mass Spectrometry 40, 160--168 (2005).
S.L. Luxembourg, L.A. McDonnell, T.H. Mize and R.M.A. Heeren, Infrared mass spectrometric imaging below the diffraction limit, Journal of Proteome Research 4, 671--673 (2005).
E. van Duijn, P.J. Bakkes, R.M.A. Heeren, R.H.H. van den Heuvel, H. van Heerikhuizen, S.M. van der Vries and A.J.R. Heck, Monitoring macromolecular complexes involved in the chaperonin-assisted protein folding cycle by mass spectrometry, Nature Methods 2, 371--376 (2005).
A.J. Kleinnijenhuis, A.J.R. Heck, M.C. Duursma and R.M.A. Heeren, Does double electron capture lead to the formation of biradicals? An ECD-SORI-CID study on lacticin 481, Journal of the American Society for Mass Spectrometry 16, 1595--1601 (2005).
R.M.A. Heeren, Proteom imaging: a closer look at life's organization, Proteomics 5, 4316--4326 (2005).
R.M.A. Heeren, Mass spectrometer identifies and localises biomarkers in cells, NPC Highlights 1, 24--27 (2005).

Article(s) published in 2004

X. Guo, M.C. Duursma, A. Al Khalili, L.A. McDonnell and R.M.A. Heeren, Design and performance of a new FT-ICR cell operating at a temperature range of 77-438 K, Int. J. Mass Spectrom. 231, 37--45 (2004).
T.H. Mize, I.M. Taban Barbu, M.C. Duursma, M. Seynen, M. Konijnenburg, A.J.M. Vijftigschild, C.J. van Doornik, G.J. van Rooij and R.M.A. Heeren, A modular data and control system to impove sensitivity, selectivity, speed of analysis, ease of use, and transient duration in an external source FTICR-MS, Int. J. Mass Spectrom. 235, 243--253 (2004).
S.L. Luxembourg, T.H. Mize, L.A. McDonnell and R.M.A. Heeren, High-spatial resolution mass spectrometric imaging of peptide and protein distributions on a surface, Anal. Chem. 76, 5339--5344 (2004).
R.M.A. Heeren, A.J. Kleinnijenhuis, L.A. McDonnell and T.H. Mize, A mini-review of mass spectrometry using high-performance FTICR-MS methods, Anal. Bioanal. Chem. 378, 1048--1058 (2004).
R. Mihalca, A.J. Kleinnijenhuis, L.A. McDonnell, M.C. Duursma, A.J.R. Heck and R.M.A. Heeren, Electron capture dissociation at low temperatures reveals selective dissociations, Journal of the American Society for Mass Spectrometry 15, 1869--1873 (2004).
J. van der Weerd, R.M.A. Heeren and J.J. Boon, Preparation methods and accessories for the infrared spectroscopic analysis of multi-layer paint films, Studies in Conservation 49, 193--210 (2004).
J. van der Weerd, M. Geldof, L.S. van der Loeff, R.M.A. Heeren and J.J. Boon, Zinc soap aggregate formation in 'falling leaves' (Les Alyscamps)' by Vincent van Gogh, Zeitschrift für Kunsttechnologie und Konservierung 17, 407--416 (2004).

Article(s) published in 2003

J. van der Weerd, M.K. van Veen, R.M.A. Heeren and J.J. Boon, Identification of pigments in paint cross sections by reflection visible light imaging microspectroscopy, Anal. Chem. 75, 716--722 (2003).
X. Guo, M.C. Duursma, A. Al Khalili and R.M.A. Heeren, Experimental calibration of SORI-CID internal energy scale: energy uptake and loss, Int. J. Mass Spectrom. 225, 71--82 (2003).
S.L. Luxembourg, L.A. McDonnell, M.C. Duursma, X. Guo and R.M.A. Heeren, Effect of local matrix crystal variations in matrix-assisted ionization techniques for mass spectrometry, Anal. Chem. 75, 2333--2341 (2003).
A.J. Kleinnijenhuis, M.C. Duursma, E. Breukink, R.M.A. Heeren and A.J.R. Heck, Localization of intramolecular monosulfide bridges in Iantibiotics determined with electron capture induced dissociation, Anal. Chem. 75, 3219--3225 (2003).
Z.W. Hendrikse, A.S.Z. Belloum, P.M.R. Jonkergouw, G.B. Eijkel, R.M.A. Heeren, B.L.O. Hertzberger, V. Korkhov, C.T.A.M. de Laat and D. Vasunin, Evaluating the VLAM-G toolkit on the DAS-2, Future Generat. Comp. Syst. 19, 815--824 (2003).
L.A. McDonnell, T.H. Mize, S.L. Luxembourg, S. Koster, G.B. Eijkel, E. Verpoorte, N.F. de Rooij and R.M.A. Heeren, Using matrix peaks to map topography: increased mass resolution enhanced sensitivity and the rapid identifacation of artifacts in chemical images, Anal. Chem. 75, 4373--4381 (2003).
M. Castillejo, M. Martín, M. Oujja, J. Santamaría, D. Silva, R. Torres, A. Manousaki, V. Zafiropulos, O.F. van den Brink, R.M.A. Heeren, R. Teule and A. Silva, Evaluation of the chemical and physical changes induced by KrF laser irradiation of tempera paints, Journal of Cultural Heritage 4, 257s--263s (2003).
R. Teule, H. Scholten, O.F. van den Brink, R.M.A. Heeren, V. Zafiropulos, R. Hesterman, M. Castillejo, M. Martín, U. Ullenius, I. Larsson, F. Guerra-Librero, A. Silva, H. Gouveia and M.-B. Albuquerque, Controlled UV laser cleaning of painted artworks: a systematic effect study on egg tempera paint samples, Journal of Cultural Heritage 4, 209s--215s (2003).
S. Koster, M.C. Duursma, J.J. Boon, R.M.A. Heeren, S. Ingemann, R.A.T.M. van Benthem and C.G. de Koster, Electron capture and collisionally activated dissociation mass spectrometry of doubly charged hyperbranched polyesteramides, Journal of the American Society for Mass Spectrometry 14, 332--341 (2003).
X. Guo, M.C. Duursma, P.G. Kistemaker, N.M.M. Nibbering, K. Vékey, L. Drahos and R.M.A. Heeren, Manipulating internal energy of protonated biomolecules in electrospray ionization Fourier transform ion cyclotron resonance mass spectrometry, Journal of Mass Spectrometry 38, 597--606 (2003).

Article(s) published in 2002

J. van der Weerd, H. Brammer, J.J. Boon and R.M.A. Heeren, Fourier Transform Infrared microscopic imaging of an embedded paint cross-section, Appl. Spectrosc. 56, 275--283 (2002).
J. van der Weerd, J.J. Boon, M. Geldof, R.M.A. Heeren and P. Noble, Chemical changes in old master paintings: dissolution, metal soap formation and remineralization processes in lead pigmented paint layers of 17th century paintings, Z. Kunsttechnol. Konserv. 16, 36--51 (2002).
G.J. van Rooij, J.J. Boon, M.C. Duursma and R.M.A. Heeren, Probing mass discriminations and mass shifts in the ITMS mass spectra of externally generated MALDI ions with synthetic polymers, Int. J. Mass Spectrom. 221, 191--207 (2002).
M. Castillejo, M. Martín, M. Oujja, D. Silva, R. Torres, A. Manousaki, V. Zafiropulos, O.F. van den Brink and R.M.A. Heeren, Analytical study of the chemical and physical changes induced by KrF laser cleaning of tempera paints, Anal. Chem. 74, 4662--4671 (2002).
S. Koster, M.C. Duursma, X. Guo, R.A.T.M.Van Benthem, C.G. de Koster, J.J. Boon and R.M.A. Heeren, Isomer seperation of hyperbranched polyesteramides with gas-phase H/D exchange and a novel MSn approach: DoDIP, Journal of Mass Spectrometry 37, 792--802 (2002).
S. Koster, B.M. Mulder, M.C. Duursma, J.J. Boon, H.J.A. Philipsen, J.W. van Velde, M.W.F. Nielen, C.G. de Koster and R.M.A. Heeren, Quantitative analysis of copolymers: influence of the structure of the monomer on the ionization efficiency in electrospray ionization FTMS, Macromolecules 35, 4919--4928 (2002).
H. Afsarmanesh, R.G. Belleman, A.S.Z. Belloum, A. Benabdelkader, J.F.J. van den Brand, G.B. Eijkel, A. Frenkel, C. Garita, D.L. Groep, R.M.A. Heeren, Z.W. Hendrikse, B.L.O. Hertzberger, J.A. Kaandorp, E.C. Kaletas, V. Korkhov, C.T.A.M. de Laat, P.M.A. Sloot, D. Vasunin, A. Visser and H.H. Yakali, VLAM-G: a grid-based virtual laboratory, Scientific Programming 10, 173--181 (2002).

Article(s) published in 2001

N. Wyplosz, R.M.A. Heeren, G.J. van Rooij and J.J. Boon, Analysis of natural organic pigments by laser desorption mass spectrometry (ldms): a preliminary study to spatially resolved mass spectrometry, Dyes History Archaeol. 16-17, 187--198 (2001).
S. Koster, C.G. de Koster, R.A.T.M.Van Benthem, M.C. Duursma, J.J. Boon and R.M.A. Heeren, Structural characterization of hyperbranched polyesteramides: MSn and the origin of species, Int. J. Mass Spectrom. 210/211, 591--602 (2001).
M.F. Bento, H. Pereira, A.M.C. Moutinho, K.-J. van den Berg, J.J. Boon, O.F. van den Brink and R.M.A. Heeren, Fragmentation of suberin and composition of aliphatic monomers released by methanolysis of cork from quercus suber L., analysed by GC-MS, SEC and MALDI-MS, Holzforschung 55, 487-493 (2001).
C.-M. Koppelman, T. den Blaauwen, M.C. Duursma, R.M.A. Heeren and N. Nanninga, Escherichia coli minicell membranes are enriched in cardiolipin, Journal of Bacteriology 183, 6144--6147 (2001).

Article(s) published in 2000

S. Koster, M.C. Duursma, J.J. Boon, M.W.F. Nielen, C.G. de Koster and R.M.A. Heeren, Structural analysis of synthetic homo- and copolyesters by electrospray ionization on a Fourier transform ion cyclotron resonance mass spectrometer, Journal of Mass Spectrometry 35, 739--748 (2000).
S. Koster, M.C. Duursma, J.J. Boon and R.M.A. Heeren, Endgroup determination of synthetic polymers by electrospray ionization Fourier transform ion cyclotron resonance mass spectrometry, Journal of the American Society for Mass Spectrometry 11, 536--543 (2000).
J.H. Scholten, J.M. Teule, V. Zafiropulos and R.M.A. Heeren, Controlled laser cleaning of painted artworks using accurate beam manipulation and on-line LIBS-detection, Journal of Cultural Heritage 1, S215--S220 (2000).
M. van de Weert, R. van 't Hof, J. van der Weerd, R.M.A. Heeren, G. Posthuma, W.E. Hennink and D.J.A. Crommelin, Lysozyme distribution and conformation in a biodegradable polymer matrix as determined by FTIR techniques, Journal of Controlled Release 68, 31--40 (2000).

Article(s) published in 1999

L. Drahos, R.M.A. Heeren, C. Collette and E. de Pauw, Thermal energy distribution observed in electrospray ionization, Journal of Mass Spectrometry 34, 1373-1379 (1999).
M.L. Easterling, I.J. Amster, G.J. van Rooij and R.M.A. Heeren, Isotope beating effects in the analysis of polymer distributions by Fourier Transform Mass Spectrometry, Journal of the American Society for Mass Spectrometry 10, 1074-1082 (1999).

Article(s) published in 1998

G.J. van Rooij, M.C. Duursma, C.G. de Koster, R.M.A. Heeren, J.J. Boon, P.J. Wijnand Schuyl and E.R.E. van der Hage, Determination of block length distributions of poly(oxypropylene) and (poly(oxyethylene) block copolymers by MALDI-FTICR mass spectrometry, Anal. Chem. 70, 843-850 (1998).

Article(s) published in 1997

P.B. O'Connor, M.C. Duursma, G.J. van Rooij, R.M.A. Heeren and J.J. Boon, Correction of time-of-flight shifted polymeric molecular weight distributions in matrix-assisted laser desorption/ionization Fourier transform mass spectrometry, Anal. Chem. 69, 2751-2755 (1997).
K. Tsumori, W.R. Koppers, R.M.A. Heeren, M.F. Kadodwala, J.H.M. Beijersbergen and A.W. Kleyn, Large ion yields in hydrogen scattering from a graphite surface, J. Appl. Phys. 81, 6390-6396 (1997).
E.R.E. van der Hage, M.C. Duursma, R.M.A. Heeren, J.J. Boon, M.W.F. Nielen, A.J.M. Weber, C.G. de Koster and N.K. de Vries, Structural analysis of polyoxyalkyleneamines by matrix-assisted laser desorption/ionization on an external ion source FT-ICR-MS and NMR, Macromolecules 30, 4302-4309 (1997).

Article(s) published in 1996

R.M.A. Heeren and J.J. Boon, Rapid microscale analyses with an external ion source Fourier transform ion cyclotron resonance mass spectrometer, Int. J. Mass Spectrom. Ion Processes 157/158, 391-403 (1996).
G.J. van Rooij, M.C. Duursma, R.M.A. Heeren, J.J. Boon and C.G. de Koster, High resolution end group determination of low molecular weight polymers by matrix-assisted laser desorption ionization on an external ion source Fourier transform ion cyclotron resonance mass spectrometer, Journal of the American Society for Mass Spectrometry 7, 449-457 (1996).

Article(s) published in 1995

C.G. de Koster, M.C. Duursma, G.J. van Rooij, R.M.A. Heeren and J.J. Boon, Endgroup analysis of polyethylene glycol polymers by matrix-assisted laser desorption/ionization Fourier-transform ion cyclotron resonance mass spectrometry, Rapid Commun. Mass Spectrom. 9, 957-962 (1995).

Article(s) published in 1994

R.M.A. Heeren, M.J. de Graaf, D. Ciric, H.J. Hopman and A.W. Kleyn, Angular and energy distributions of surface produced H- and D- ions in a barium surface conversion source, J. Appl. Phys. 75, 4340-4351 (1994).

Article(s) published in 1993

R.M.A. Heeren, D.B. Meyler, D. Ciric, H.J. Hopman and A.W. Kleyn, Hydrogen and deuterium depth profiles in a barium surface converter determined by LAMS and P-SNMS, Appl. Surf. Sci. 68, 265-274 (1993).
R.M.A. Heeren, M.J. de Graaf, D. Ciric, H.J. Hopman and A.W. Kleyn, Energetic "self-extracted" H- ions in a Ba surface conversion source, Appl. Surf. Sci. 70/71, 332-336 (1993).

Article(s) published in 1992

R.M.A. Heeren, K.N. Mellon, M.B. Hopkins, D. Ciric and A.W. Kleyn, Investigation of the extracted H- current in a continuously pulsed-volume negative-ion source, Europhys. Lett. 17, 503-508 (1992).
R.M.A. Heeren, D. Ciric, S. Yagura, H.J. Hopman and A.W. Kleyn, Sputtering of a hydrogenated barium surface in a negative ion surface conversion source, Nucl. Instrum. Methods Phys. Res. B 69, 389-402 (1992).

Article(s) published in 1991

R.M.A. Heeren, D. Ciric, H.J. Hopman and A.W. Kleyn, Enhanced preferential sputtering of a hydrogenated barium surface, Appl. Phys. Lett. 59, 158-160 (1991).

Article(s) published in 1989

H.M. van Pinxteren, C.F.A. van Os, R.M.A. Heeren, R. Rodink, J.J.C. Geerlings and J.H. Los, Angular "Selection Rules" for the resonant population of O-(2P) and C-(4S) in grazing ion-surface collisions, Europhys. Lett. 10, 715-719 (1989).
P.J. Eenshuistra, R.M.A. Heeren, A.W. Kleyn and H.J. Hopman, Dissociation and vibrational excitation of H2 molecules and wall influence on the densities in a multicusp ion source, Physical Review A 40, 3613-3625 (1989).

Article(s) published in 1987

C.F.A. van Os, R.M.A. Heeren and P.W. van Amersfoort, Negative ion formation at a barium surface in contact with a hydrogen plasma, Appl. Phys. Lett. 51, 1495-1497 (1987).